Loss of Sirt1 function improves intestinal anti-bacterial defense and protects from colitis-induced colorectal cancer.

Loss of Sirt1 function improves intestinal anti-bacterial defense and protects from colitis-induced colorectal cancer.

Dysfunction of Paneth and goblet cells in the intestine contributes to inflammatory bowel disease (IBD) and colitis-associated colorectal cancer (CAC). Here, we report a role for the NAD+-dependent histone deacetylase SIRT1 in the control of anti-bacterial defense. Mice with an intestinal specific S...

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Bibliographic Details
Main Authors: Giuseppe Lo Sasso, Dongryeol Ryu, Laurent Mouchiroud, Samodha C Fernando, Christopher L Anderson, Elena Katsyuba, Alessandra Piersigilli, Michael O Hottiger, Kristina Schoonjans, Johan Auwerx
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4094521?pdf=render

Internet

http://europepmc.org/articles/PMC4094521?pdf=render

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