A Neuroprotective Dose of Isatin Causes Multilevel Changes Involving the Brain Proteome: Prospects for Further Research

A Neuroprotective Dose of Isatin Causes Multilevel Changes Involving the Brain Proteome: Prospects for Further Research

Isatin (indole-2,3-dione) is an endogenous regulator, exhibiting a wide range of biological and pharmacological activities. At doses of 100 mg/kg and above, isatin is neuroprotective in different experimental models of neurodegeneration. Good evidence exists that its effects are realized via interac...

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Bibliographic Details
Main Authors: Alexei Medvedev, Arthur Kopylov, Olga Buneeva, Leonid Kurbatov, Olga Tikhonova, Alexis Ivanov, Victor Zgoda
Format: Article
Language:English
Published: MDPI AG 2020-06-01
Series:International Journal of Molecular Sciences
Subjects:
neuroprotector isatin
molecular targets
differentially expressed proteins
proteome analysis
isatin-binding proteins
interactome
Online Access:https://www.mdpi.com/1422-0067/21/11/4187

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https://www.mdpi.com/1422-0067/21/11/4187

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