Imidazopyridines as Potent KDM5 Demethylase Inhibitors Promoting Reprogramming Efficiency of Human iPSCs

Imidazopyridines as Potent KDM5 Demethylase Inhibitors Promoting Reprogramming Efficiency of Human iPSCs

Summary: Pioneering human induced pluripotent stem cell (iPSC)-based pre-clinical studies have raised safety concerns and pinpointed the need for safer and more efficient approaches to generate and maintain patient-specific iPSCs. One approach is searching for compounds that influence pluripotent st...

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Bibliographic Details
Main Authors: Yasamin Dabiri, Rodrigo A. Gama-Brambila, Katerina Taškova, Kristina Herold, Stefanie Reuter, James Adjaye, Jochen Utikal, Ralf Mrowka, Jichang Wang, Miguel A. Andrade-Navarro, Xinlai Cheng
Format: Article
Language:English
Published: Elsevier 2019-02-01
Series:iScience
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004219300124

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http://www.sciencedirect.com/science/article/pii/S2589004219300124

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