Synthesis, In Vitro Biological Evaluation and In Silico Molecular Docking Studies of Indole Based Thiadiazole Derivatives as Dual Inhibitor of Acetylcholinesterase and Butyrylchloinesterase

Synthesis, In Vitro Biological Evaluation and In Silico Molecular Docking Studies of Indole Based Thiadiazole Derivatives as Dual Inhibitor of Acetylcholinesterase and Butyrylchloinesterase

The current study was conducted to obtain hybrid analogues of indole-based thiadiazole derivatives (<b>1</b>–<b>16</b>) in which a number of reaction steps were involved. To examine their biological activity in the presence of the reference drug Donepezil (0.21 ± 0.12 and 0.3...

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Bibliographic Details
Main Authors: Shoaib Khan, Shahid Iqbal, Muhammad Taha, Fazal Rahim, Mazloom Shah, Hayat Ullah, Ali Bahadur, Hamad Alrbyawi, Ayed A. Dera, Mohammed Issa Alahmdi, Rami Adel Pashameah, Eman Alzahrani, Abd-ElAziem Farouk
Format: Article
Language:English
Published: MDPI AG 2022-10-01
Series:Molecules
Subjects:
indole
thiadiazole analogs
SAR
AchE and BuChE inhibitors
molecular docking
Online Access:https://www.mdpi.com/1420-3049/27/21/7368

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https://www.mdpi.com/1420-3049/27/21/7368

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