Prophylactic Treatment With Simvastatin Modulates the Immune Response and Increases Animal Survival Following Lethal Sepsis Infection

Prophylactic Treatment With Simvastatin Modulates the Immune Response and Increases Animal Survival Following Lethal Sepsis Infection

Chronic use of statins may have anti-inflammatory action, promoting immunomodulation and survival in patients with sepsis. This study aimed to analyze the effects of pretreatment with simvastatin in lethal sepsis induced by cecal ligation and puncture (CLP). Male Swiss mice received prophylactic tre...

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Bibliographic Details
Main Authors: Jose A. F. Braga Filho, Afonso G. Abreu, Carlos E. P. Rios, Liana O. Trovão, Dimitri Luz F. Silva, Dalila N. Cysne, Johnny R. Nascimento, Thiare S. Fortes, Lucilene A. Silva, Rosane N. M. Guerra, Márcia C. G. Maciel, Carlos H. Serezani, Flávia R. F. Nascimento
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-09-01
Series:Frontiers in Immunology
Subjects:
simvastatin
prophylactic treatment
sepsis
immunomodulation
macrophages
hydrogen peroxide
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.02137/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2018.02137/full

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