Free heme induces neuroinflammation and cognitive impairment by microglial activation via the TLR4/MyD88/NF-κB signaling pathway

Free heme induces neuroinflammation and cognitive impairment by microglial activation via the TLR4/MyD88/NF-κB signaling pathway

Abstract Background Red blood cells (RBCs) transfusion is related to perioperative neurocognitive disorders. The toxic effect of free heme has been identified in many pathologies. However, the underlying mechanisms of RBCs transfusion or free heme in cognitive impairment have not been clearly explor...

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Bibliographic Details
Main Authors: Xin Wei, Fan Zhang, Dan Cheng, Zhongyu Wang, Na Xing, Jingjing Yuan, Wei Zhang, Fei Xing
Format: Article
Language:English
Published: BMC 2024-01-01
Series:Cell Communication and Signaling
Subjects:
Free heme
Cognitive function
Neuroinflammation
Neuron
Microglia activation
TLR4/MyD88/NF-κB
Online Access:https://doi.org/10.1186/s12964-023-01387-8

Internet

https://doi.org/10.1186/s12964-023-01387-8

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