Endoplasmic reticulum stress mediates nickel chloride-induced epithelial‑mesenchymal transition and migration of human lung cancer A549 cells through Smad2/3 and p38 MAPK activation

Endoplasmic reticulum stress mediates nickel chloride-induced epithelial‑mesenchymal transition and migration of human lung cancer A549 cells through Smad2/3 and p38 MAPK activation

Background: The endoplasmic reticulum (ER) is a cellular membrane-bound organelle whereby proteins are synthesized, folded and glycosylated. Due to intrinsic (e.g., genetic) and extrinsic (e.g., environmental stressors) perturbations, ER proteostasis can be deregulated within cells which triggers un...

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Main Authors: Mengping Yu, Feipeng Chen, Haopei Wang, Qianlei Fu, Lingzi Yan, Zhao Chen, Huijun Li, Miaomiao Jia, Dalong Yang, Xiaohui Hua, Tong Shen, Qixing Zhu, Chengfan Zhou
Format: Article
Jezik:English
Izdano: Elsevier 2023-01-01
Serija:Ecotoxicology and Environmental Safety
Teme:
Nickel chloride
Endoplasmic reticulum stress
Epithelial-mesenchymal transition
Migration
A549 cell
Online dostop:http://www.sciencedirect.com/science/article/pii/S0147651322012386

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http://www.sciencedirect.com/science/article/pii/S0147651322012386

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