Inactivation of the Euchromatic Histone-Lysine N-Methyltransferase 2 Pathway in Pancreatic Epithelial Cells Antagonizes Cancer Initiation and Pancreatitis-Associated Promotion by Altering Growth and Immune Gene Expression Networks

Inactivation of the Euchromatic Histone-Lysine N-Methyltransferase 2 Pathway in Pancreatic Epithelial Cells Antagonizes Cancer Initiation and Pancreatitis-Associated Promotion by Altering Growth and Immune Gene Expression Networks

Pancreatic ductal adenocarcinoma (PDAC) is an aggressive, painful disease with a 5-year survival rate of only 9%. Recent evidence indicates that distinct epigenomic landscapes underlie PDAC progression, identifying the H3K9me pathway as important to its pathobiology. Here, we delineate the role of E...

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Bibliographic Details
Main Authors: Guillermo Urrutia, Thiago Milech de Assuncao, Angela J. Mathison, Ann Salmonson, Romica Kerketta, Atefeh Zeighami, Timothy J. Stodola, Volkan Adsay, Burcin Pehlivanoglu, Michael B. Dwinell, Michael T. Zimmermann, Juan L. Iovanna, Raul Urrutia, Gwen Lomberk
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-06-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
pancreatic carcinoma
epigenomics
histone methyltransferases
gene regulatory networks
tumor microenvironment
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2021.681153/full

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https://www.frontiersin.org/articles/10.3389/fcell.2021.681153/full

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