Effective sequential combined therapy with carboplatin and a CDC7 inhibitor in ovarian cancer

Effective sequential combined therapy with carboplatin and a CDC7 inhibitor in ovarian cancer

Background: The enhancement of DNA damage repair is one of the important mechanisms of platinum resistance. Protein cell division cycle 7 (CDC7) is a conserved serine/threonine kinase that plays important roles in the initiation of DNA replication and is associated with chemotherapy resistance in ov...

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Bibliographic Details
Main Authors: Junping Li, Hong Hu, Jinping He, Yuling Hu, Manting Liu, Bihui Cao, Dongni Chen, Xiaodie Ye, Jian Zhang, Zhiru Zhang, Wen Long, Hui Lian, Deji Chen, Likun Chen, Lili Yang, Zhenfeng Zhang
Format: Article
Language:English
Published: Elsevier 2024-01-01
Series:Translational Oncology
Subjects:
Ovarian cancer
Carboplatin
CDC7 inhibitor
Homologous recombination repair
Online Access:http://www.sciencedirect.com/science/article/pii/S1936523323002115

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http://www.sciencedirect.com/science/article/pii/S1936523323002115

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