Oncostatin M suppresses IL31RA expression in dorsal root ganglia and interleukin-31-induced itching

Oncostatin M suppresses IL31RA expression in dorsal root ganglia and interleukin-31-induced itching

BackgroundAtopic dermatitis (AD) is a chronic inflammatory skin disease characterized by intermittent itchy rash. Type 2 inflammatory cytokines such as interleukin (IL)-4, IL-13, and IL-31 are strongly implicated in AD pathogenesis. Stimulation of IL-31 cognate receptors on C-fiber nerve endings is...

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Bibliographic Details
Main Authors: Masataka Suehiro, Tomofumi Numata, Ryo Saito, Nozomi Yanagida, Chie Ishikawa, Kazue Uchida, Tomoko Kawaguchi, Yuhki Yanase, Yozo Ishiuji, John McGrath, Akio Tanaka
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-11-01
Series:Frontiers in Immunology
Subjects:
oncostatin M
atopic dermatitis
IL-31
itch
pruritus
IL31RA
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1251031/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2023.1251031/full

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