Essential Regulation of Lung Surfactant Homeostasis by the Orphan G Protein-Coupled Receptor GPR116

Essential Regulation of Lung Surfactant Homeostasis by the Orphan G Protein-Coupled Receptor GPR116

GPR116 is an orphan seven-pass transmembrane receptor whose function has been unclear. Global disruption of the Gpr116 gene in mice revealed an unexpected, critical role for this receptor in lung surfactant homeostasis, resulting in progressive accumulation of surfactant lipids and proteins in the a...

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Bibliographic Details
Main Authors: Mi Young Yang, Mary Beth Hilton, Steven Seaman, Diana C. Haines, Kunio Nagashima, Christina M. Burks, Lino Tessarollo, Pavlina T. Ivanova, H. Alex Brown, Todd M. Umstead, Joanna Floros, Zissis C. Chroneos, Brad St. Croix
Format: Article
Language:English
Published: Elsevier 2013-05-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124713002015

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http://www.sciencedirect.com/science/article/pii/S2211124713002015

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