Matrix metalloproteinase-9 inhibition prevents aquaporin-4 depolarization-mediated glymphatic dysfunction in Parkinson’s disease

Matrix metalloproteinase-9 inhibition prevents aquaporin-4 depolarization-mediated glymphatic dysfunction in Parkinson’s disease

Introduction: The glymphatic system offers a perivascular pathway for the clearance of pathological proteins and metabolites to optimize neurological functions. Glymphatic dysfunction plays a pathogenic role in Parkinson's disease (PD); however, the molecular mechanism of glymphatic dysfunction...

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Bibliographic Details
Main Authors: Xiaoli Si, Shaobing Dai, Yi Fang, Jiahui Tang, Zhiyun Wang, Yaolin Li, Zhe Song, Ying Chen, Yi Liu, Guohua Zhao, Baorong Zhang, Jiali Pu
Format: Article
Language:English
Published: Elsevier 2024-02-01
Series:Journal of Advanced Research
Subjects:
Parkinson’s disease
Glymphatic system
Aquaporin-4
Matrix metalloproteinase-9
Metabolomics
Online Access:http://www.sciencedirect.com/science/article/pii/S2090123223000863

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http://www.sciencedirect.com/science/article/pii/S2090123223000863

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