Domain motions, dimerization, and membrane interactions of the murine guanylate binding protein 2

Abstract Guanylate-binding proteins (GBPs) are a group of GTPases that are induced by interferon- $$\gamma$$ γ and are crucial components of cell-autonomous immunity against intracellular pathogens. Here, we examine murine GBP2 (mGBP2), which we have previously shown to be an essential effector prot...

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Bibliographic Details
Main Authors: Jennifer Loschwitz, Nora Steffens, Xue Wang, Moritz Schäffler, Klaus Pfeffer, Daniel Degrandi, Birgit Strodel
Format: Article
Language:English
Published: Nature Portfolio 2023-01-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-023-27520-8