Cancer-associated fibroblasts-derived CXCL12 enhances immune escape of bladder cancer through inhibiting P62-mediated autophagic degradation of PDL1

Cancer-associated fibroblasts-derived CXCL12 enhances immune escape of bladder cancer through inhibiting P62-mediated autophagic degradation of PDL1

Abstract Background Cancer-associated fibroblasts (CAFs), the predominant stromal cell of tumor microenvironment (TME), play an important role in tumor progression and immunoregulation by remodeling extracellular matrix (ECM) and secreting cytokines. However, little is known about the details of the...

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Bibliographic Details
Main Authors: Zhao Zhang, Yongbo Yu, Zhilei Zhang, Dan Li, Zhijuan Liang, Liping Wang, Yuanbin Chen, Ye Liang, Haitao Niu
Format: Article
Language:English
Published: BMC 2023-11-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Cancer-associated fibroblast
CXCL12
PDL1
Autophagy
P62
Immune escape
Online Access:https://doi.org/10.1186/s13046-023-02900-0

Internet

https://doi.org/10.1186/s13046-023-02900-0

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