Fates of retroviral core components during unrestricted and TRIM5-restricted infection.

TRIM5 proteins can restrict retroviral infection soon after delivery of the viral core into the cytoplasm. However, the molecular mechanisms by which TRIM5α inhibits infection have been elusive, in part due to the difficulty of developing and executing biochemical assays that examine this stage of t...

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Bibliographic Details
Main Authors: Sebla B Kutluay, David Perez-Caballero, Paul D Bieniasz
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-03-01
Series:PLoS Pathogens
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23505372/?tool=EBI