In-silico investigations of novel tacrine derivatives potency against Alzheimer's disease

In-silico investigations of novel tacrine derivatives potency against Alzheimer's disease

Tacrine was originally used as a palliative treatment for Alzheimer's disease (AD). But early applications soon revealed a number of its side effects on human health. That's why we decided to examine the effectiveness of novel tacrine derivatives known for their potent inhibition of GluN2B...

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Bibliographic Details
Main Authors: Mohamed El fadili, Mohammed Er-rajy, Mohnad Abdalla, Hatem A. Abuelizz, Sara Zarougui, Fadwa Mohammed Alkhulaifi, Nada F Alahmady, Ashwag Shami, Menana Elhallaoui
Format: Article
Language:English
Published: Elsevier 2024-03-01
Series:Scientific African
Subjects:
NMDA receptor
Alzheimer's disease
3D-QSAR
ADME-toxicity
Molecular docking
Molecular dynamics
Online Access:http://www.sciencedirect.com/science/article/pii/S2468227623005021

Internet

http://www.sciencedirect.com/science/article/pii/S2468227623005021

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