Single intranasal immunization with attenuated Wuhan-like SARS-CoV-2 provides highly effective cross-protection against Delta and Omicron variants of concern

Single intranasal immunization with attenuated Wuhan-like SARS-CoV-2 provides highly effective cross-protection against Delta and Omicron variants of concern

Introduction. Despite the end of the COVID-19 pandemic, the problem of vaccine prevention of this disease appears highly relevant. The emergence and widespread distribution of the Omicron SARS-CoV-2 variant of concern (VOC) and its sublineages has dramatically reduced the efficacy of vaccination. Th...

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Bibliographic Details
Main Authors: Evgeny B. Faizuloev, Anastasiia V. Gracheva, Ekaterina R. Korchevaya, Yulia I. Ammour, Daria I. Smirnova, Darya M. Khokhlova, Andrey O. Drokov, Andrey A. Pankratov, Galina V. Trunova, Varvara A. Khokhlova, Maria S. Vorontsova, Irina A. Leneva, Oksana A. Svitich, Vitaly V. Zverev
Format: Article
Language:Russian
Published: Central Research Institute for Epidemiology 2024-03-01
Series:Журнал микробиологии, эпидемиологии и иммунобиологии
Subjects:
live attenuated covid-19 vaccine
cold-adapted sars-cov-2
immunization efficacy
intranasal immunization
heterologous challenge
cross-protective immune response
golden syrian hamsters
Online Access:https://microbiol.crie.ru/jour/article/viewFile/18552/1401

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https://microbiol.crie.ru/jour/article/viewFile/18552/1401

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