Lentivirus-Mediated BCL-X<sub>L</sub> Overexpression Inhibits Stem Cell Apoptosis during Ex Vivo Expansion and Provides Competitive Advantage Following Xenotransplantation

Lentivirus-Mediated BCL-X<sub>L</sub> Overexpression Inhibits Stem Cell Apoptosis during Ex Vivo Expansion and Provides Competitive Advantage Following Xenotransplantation

Hematopoietic reconstitution after hematopoietic stem cell transplantation (HSCT) is influenced by the number of transplanted cells. However, under certain conditions donor cell counts are limited and impair clinical outcome. Hematopoietic stem and progenitor cell (HSPC) expansion prior to HSCT is a...

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Bibliographic Details
Main Authors: Patricia M. A. Zehnle, Ying Wu, Naile Koleci, Sheila Bohler, Miriam Erlacher
Format: Article
Language:English
Published: MDPI AG 2024-04-01
Series:International Journal of Molecular Sciences
Subjects:
hematopoietic stem cells
apoptosis
BCL-2
BCL-X<sub>L</sub>
caspases
Online Access:https://www.mdpi.com/1422-0067/25/7/4105

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https://www.mdpi.com/1422-0067/25/7/4105

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