The dynamic of changes of pNFH levels in the CSF compared with the motor scales’ scores during three years of nusinersen treatment in children with spinal muscular atrophy types 2 and 3

The dynamic of changes of pNFH levels in the CSF compared with the motor scales’ scores during three years of nusinersen treatment in children with spinal muscular atrophy types 2 and 3

Neurofilaments are crucial in neuronal cytoskeleton formation, influencing axonal growth and impulse modulation. This study focuses on understanding the dynamics of the phosphorylated neurofilament heavy subunit (pNFH) in pediatric spinal muscular atrophy (SMA) patients un-dergoing Nusinersen treatm...

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Príomhchruthaitheoirí: Mihaela Badina, Corina Sporea, Gabriel Cristian Bejan, Andrada Mirea, Daniela Adriana Ion
Formáid: Alt
Teanga:English
Foilsithe / Cruthaithe: Romanian Association of Balneology, Editura Balneara 2024-03-01
Sraith:Balneo and PRM Research Journal
Ábhair:
neurofilaments; phosphorylated neurofilament heavy subunit (pnfh)
spinal muscular atrophy (sma); smn2 gene
nusinersen
biomarkers
pediatric population
motor function
cerebrospinal fluid (csf)
treatment efficacy
Rochtain ar líne:https://bioclima.ro/Balneo643.pdf

Ar líne

https://bioclima.ro/Balneo643.pdf

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