Blockade of Uttroside B-Induced Autophagic Pro-Survival Signals Augments Its Chemotherapeutic Efficacy Against Hepatocellular Carcinoma

Blockade of Uttroside B-Induced Autophagic Pro-Survival Signals Augments Its Chemotherapeutic Efficacy Against Hepatocellular Carcinoma

Our previous study has demonstrated that Uttroside B (Utt-B), a saponin isolated from the leaves of Solanum nigrum Linn induces apoptosis in hepatic cancer cells and exhibits a remarkable growth inhibition of Hepatocellular Carcinoma (HCC). Our innovation has been granted a patent from the US (US 20...

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Bibliographic Details
Main Authors: Lekshmi R. Nath, Mundanattu Swetha, Vinod Vijayakurup, Arun Kumar Thangarasu, Nair Hariprasad Haritha, Anwar Shabna, Sreekumar U. Aiswarya, Tennyson P. Rayginia, C. K. Keerthana, Kalishwaralal Kalimuthu, Sankar Sundaram, Ravi Shankar Lankalapalli, Sreekumar Pillai, Rheal Towner, Noah Isakov, Ruby John Anto
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-02-01
Series:Frontiers in Oncology
Subjects:
autophagy
chloroquine
apoptosis
uttroside B
hepatocellular carcinoma
chemoprevention
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2022.812598/full

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https://www.frontiersin.org/articles/10.3389/fonc.2022.812598/full

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