Splicing repression allows the gradual emergence of new Alu-exons in primate evolution

Splicing repression allows the gradual emergence of new Alu-exons in primate evolution

Alu elements are retrotransposons that frequently form new exons during primate evolution. Here, we assess the interplay of splicing repression by hnRNPC and nonsense-mediated mRNA decay (NMD) in the quality control and evolution of new Alu-exons. We identify 3100 new Alu-exons and show that NMD mor...

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Bibliographic Details
Main Authors: Jan Attig, Igor Ruiz de los Mozos, Nejc Haberman, Zhen Wang, Warren Emmett, Kathi Zarnack, Julian König, Jernej Ule
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2016-11-01
Series:eLife
Subjects:
pre-mRNA processing
Alu elements
nonsense mediated mRNA decay
exon evolution
splicing fidelity
Online Access:https://elifesciences.org/articles/19545

Internet

https://elifesciences.org/articles/19545

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