Tau and spectraplakins promote synapse formation and maintenance through Jun kinase and neuronal trafficking

Tau and spectraplakins promote synapse formation and maintenance through Jun kinase and neuronal trafficking

The mechanisms regulating synapse numbers during development and ageing are essential for normal brain function and closely linked to brain disorders including dementias. Using Drosophila, we demonstrate roles of the microtubule-associated protein Tau in regulating synapse numbers, thus unravelling...

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Bibliographic Details
Main Authors: Andre Voelzmann, Pilar Okenve-Ramos, Yue Qu, Monika Chojnowska-Monga, Manuela del Caño-Espinel, Andreas Prokop, Natalia Sanchez-Soriano
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2016-08-01
Series:eLife
Subjects:
axons
microtubules
synapses
neurodegeneration
transport
tau
Online Access:https://elifesciences.org/articles/14694

Internet

https://elifesciences.org/articles/14694

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