In FUS[1−359]‐tg mice O,S-dibenzoyl thiamine reduces muscle atrophy, decreases glycogen synthase kinase 3 beta, and normalizes the metabolome

In FUS[1−359]‐tg mice O,S-dibenzoyl thiamine reduces muscle atrophy, decreases glycogen synthase kinase 3 beta, and normalizes the metabolome

Mutations in the gene encoding the RNA/DNA-binding protein Fused in Sarcoma (FUS) have been detected in familial amyotrophic lateral sclerosis (ALS) patients. FUS has been found to be a critical component of the oxidative damage repair complex that might explain its role in neurodegeneration. Here,...

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Bibliographic Details
Main Authors: Fay Probert, Anna Gorlova, Alexei Deikin, Lucien Bettendorff, Ekaterina Veniaminova, Andrey Nedorubov, Kirill D. Chaprov, Tamara A. Ivanova, Daniel C. Anthony, Tatyana Strekalova
Format: Article
Language:English
Published: Elsevier 2022-12-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Amyotrophic lateral sclerosis
Fused in Sarcoma protein
Thiamine
Neuroinflammation
Cytokine
Lactate
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332222013750

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http://www.sciencedirect.com/science/article/pii/S0753332222013750

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