The Conformationally Sensitive Spatial Distance Between the TM3-4 Loop and Transmembrane Segment 7 in the Glutamate Transporter Revealed by Paired-Cysteine Mutagenesis

The Conformationally Sensitive Spatial Distance Between the TM3-4 Loop and Transmembrane Segment 7 in the Glutamate Transporter Revealed by Paired-Cysteine Mutagenesis

Excitatory amino acid transporters can maintain extracellular glutamate concentrations lower than neurotoxic levels by transferring neurotransmitters from the synaptic cleft into surrounding glial cells and neurons. Previous work regarding the structural studies of GltPh, GltTK, excitatory amino aci...

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Bibliographic Details
Main Authors: Qi Qu, Ji Wang, Guiping Li, Rongqing Chen, Shaogang Qu
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-09-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
EAAT2
TM3-TM4 loop
TM7
cross-linking
paired-cysteine mutagenesis
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2021.737629/full

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https://www.frontiersin.org/articles/10.3389/fcell.2021.737629/full

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