Developing an Anion Exchange Chromatography Assay for Determining Empty and Full Capsid Contents in AAV6.2

Developing an Anion Exchange Chromatography Assay for Determining Empty and Full Capsid Contents in AAV6.2

Adeno-associated virus (AAV) vectors are clinically proven gene delivery vehicles that are attracting an increasing amount of attention. Non-genome-containing empty AAV capsids are by-products during AAV production that have been reported to potentially impact AAV product safety and efficacy. Theref...

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Bibliographic Details
Main Authors: Chunlei Wang, Sri Hari Raju Mulagapati, Zhongying Chen, Jing Du, Xiaohui Zhao, Guoling Xi, Liyan Chen, Thomas Linke, Cuihua Gao, Albert E. Schmelzer, Dengfeng Liu
Format: Article
Language:English
Published: Elsevier 2019-12-01
Series:Molecular Therapy: Methods & Clinical Development
Online Access:http://www.sciencedirect.com/science/article/pii/S2329050119301044

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http://www.sciencedirect.com/science/article/pii/S2329050119301044

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