Poly(I:C) Induces Distinct Liver Cell Type-Specific Responses in Hepatitis B Virus-Transgenic Mice In Vitro, but Fails to Induce These Signals In Vivo

Poly(I:C) Induces Distinct Liver Cell Type-Specific Responses in Hepatitis B Virus-Transgenic Mice In Vitro, but Fails to Induce These Signals In Vivo

Immunopathology in hepatitis B virus (HBV) infection is driven by innate and adaptive immunity. Whether the hepatitis B surface antigen (HBsAg) affects hepatic antiviral signalling was investigated in HBV-transgenic mouse models that either accumulate (Alb/HBs, Tg[Alb1HBV]Bri44), lack (Tg1.4HBV-s-mu...

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Bibliographic Details
Main Authors: Stefan Schefczyk, Xufeng Luo, Yaojie Liang, Martin Trippler, Mengji Lu, Heiner Wedemeyer, Hartmut H. Schmidt, Ruth Broering
Format: Article
Language:English
Published: MDPI AG 2023-05-01
Series:Viruses
Subjects:
hepatitis B virus
hepatitis B surface antigen
immune evasion
pattern recognition
toll-like receptor
Online Access:https://www.mdpi.com/1999-4915/15/5/1203

Internet

https://www.mdpi.com/1999-4915/15/5/1203

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