Yin-Yang 1 and HBx protein activate HBV transcription by mediating the spatial interaction of cccDNA minichromosome with cellular chromosome 19p13.11

Yin-Yang 1 and HBx protein activate HBV transcription by mediating the spatial interaction of cccDNA minichromosome with cellular chromosome 19p13.11

ABSTRACTHBV cccDNA stably exists in the nuclei of infected cells as an episomal munichromosome which is responsible for viral persistence and failure of current antiviral treatments. However, the regulatory mechanism of cccDNA transcription by viral and host cellular factors is not well understood....

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Bibliographic Details
Main Authors: Congle Shen, Xiaoyu Feng, Tianhao Mao, Danli Yang, Jun Zou, Xiaobin Zao, Qiang Deng, Xiangmei Chen, Fengmin Lu
Format: Article
Language:English
Published: Taylor & Francis Group 2020-01-01
Series:Emerging Microbes and Infections
Subjects:
HBV cccDNA
HBV transcription regulation
spatial interaction
chromosome 19p13.11
YY1
Online Access:https://www.tandfonline.com/doi/10.1080/22221751.2020.1840311

Internet

https://www.tandfonline.com/doi/10.1080/22221751.2020.1840311

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