SPAG5 deficiency activates autophagy to reduce atherosclerotic plaque formation in ApoE−/− mice

SPAG5 deficiency activates autophagy to reduce atherosclerotic plaque formation in ApoE−/− mice

Abstract Background Autophagy, as a regulator of cell survival, plays an important role in atherosclerosis (AS). Sperm associated antigen 5 (SPAG5) is closely associated with the classical autophagy pathway, PI3K/Akt/mTOR signaling pathway. This work attempted to investigate whether SPAG5 can affect...

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Bibliografski detalji
Glavni autori: Liangyun Guo, Huijing Yuan, Huayao Zhu, Jie Zhou, Zixin Wan, Yihua Zhou
Format: Članak
Jezik:English
Izdano: BMC 2024-05-01
Serija:BMC Cardiovascular Disorders
Teme:
Autophagy
Atherosclerosis
SPAG5
PI3K/Akt/mTOR
Online pristup:https://doi.org/10.1186/s12872-024-03945-5

Internet

https://doi.org/10.1186/s12872-024-03945-5

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