Role of glutamic acid decarboxylase 67 in regulating cortical parvalbumin and GABA membrane transporter 1 expression: Implications for schizophrenia

Role of glutamic acid decarboxylase 67 in regulating cortical parvalbumin and GABA membrane transporter 1 expression: Implications for schizophrenia

Markers of GABA neurotransmission are altered in multiple regions of the neocortex in individuals with schizophrenia. Lower levels of glutamic acid decarboxylase 67 (GAD67) mRNA and protein, which is responsible for most cortical GABA synthesis, are accompanied by lower levels of GABA membrane trans...

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Bibliographic Details
Main Authors: Allison A. Curley, Stephen M. Eggan, Matt S. Lazarus, Z. Josh Huang, David W. Volk, David A. Lewis
Format: Article
Language:English
Published: Elsevier 2013-02-01
Series:Neurobiology of Disease
Subjects:
Glutamic acid decarboxylase
GABA transporter
Parvalbumin
Prefrontal cortex
Schizophrenia
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996112003464

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