SLC-0111, an inhibitor of carbonic anhydrase IX, attenuates hepatoblastoma cell viability and migration

SLC-0111, an inhibitor of carbonic anhydrase IX, attenuates hepatoblastoma cell viability and migration

BackgroundIn response to hypoxia, tumor cells undergo transcriptional reprogramming including upregulation of carbonic anhydrase (CA) IX, a metalloenzyme that maintains acid-base balance. CAIX overexpression has been shown to correlate with poor prognosis in various cancers, but the role of this CA...

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Bibliographic Details
Main Authors: Katja Eloranta, Marjut Pihlajoki, Emmi Liljeström, Ruth Nousiainen, Tea Soini, Jouko Lohi, Stefano Cairo, David B. Wilson, Seppo Parkkila, Markku Heikinheimo
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-01-01
Series:Frontiers in Oncology
Subjects:
carbonic anhydrase IX
hepatoblastoma
pediatric oncology
tumor hypoxia
targeted therapy
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2023.1118268/full

Internet

https://www.frontiersin.org/articles/10.3389/fonc.2023.1118268/full

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