Nanomicelles of Radium Dichloride [<sup>223</sup>Ra]RaCl<sub>2</sub> Co-Loaded with Radioactive Gold [<sup>198</sup>Au]Au Nanoparticles for Targeted Alpha–Beta Radionuclide Therapy of Osteosarcoma
Alpha and beta particulate radiation are used for non-treated neoplasia, due to their ability to reach and remain in tumor sites. Radium-223 (<sup>223</sup>Ra), an alpha emitter, promotes localized cytotoxic effects, while radioactive gold (<sup>198</sup>Au), beta-type energy...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-03-01
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| Series: | Polymers |
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| Online Access: | https://www.mdpi.com/2073-4360/14/7/1405 |
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| author | Bárbara Nayane Rosário Fernandes Souza Elisabete Regina Fernandes Ramos Ribeiro Aline Oliveira da Silva de Barros Martha Sahylí Ortega Pijeira Hericka Oliveira Kenup-Hernandes Eduardo Ricci-Junior Joel Félix Silva Diniz Filho Clenilton Costa dos Santos Luciana Magalhães Rebelo Alencar Mohamed F. Attia Sara Gemini-Piperni Ralph Santos-Oliveira |
| author_facet | Bárbara Nayane Rosário Fernandes Souza Elisabete Regina Fernandes Ramos Ribeiro Aline Oliveira da Silva de Barros Martha Sahylí Ortega Pijeira Hericka Oliveira Kenup-Hernandes Eduardo Ricci-Junior Joel Félix Silva Diniz Filho Clenilton Costa dos Santos Luciana Magalhães Rebelo Alencar Mohamed F. Attia Sara Gemini-Piperni Ralph Santos-Oliveira |
| author_sort | Bárbara Nayane Rosário Fernandes Souza |
| collection | DOAJ |
| description | Alpha and beta particulate radiation are used for non-treated neoplasia, due to their ability to reach and remain in tumor sites. Radium-223 (<sup>223</sup>Ra), an alpha emitter, promotes localized cytotoxic effects, while radioactive gold (<sup>198</sup>Au), beta-type energy, reduces radiation in the surrounding tissues. Nanotechnology, including several radioactive nanoparticles, can be safely and effectively used in cancer treatment. In this context, this study aims to analyze the antitumoral effects of [<sup>223</sup>Ra]Ra nanomicelles co-loaded with radioactive gold nanoparticles ([<sup>198</sup>Au]AuNPs). For this, we synthesize and characterize nanomicelles, as well as analyze some parameters, such as particle size, radioactivity emission, dynamic light scattering, and microscopic atomic force. [<sup>223</sup>Ra]Ra nanomicelles co-loaded with [<sup>198</sup>Au]AuNPs, with simultaneous alpha and beta emission, showed no instability, a mean particle size of 296 nm, and a PDI of 0.201 (±0.096). Furthermore, nanomicelles were tested in an in vitro cytotoxicity assay. We observed a significant increase in tumor cell death using combined alpha and beta therapy in the same formulation, compared with these components used alone. Together, these results show, for the first time, an efficient association between alpha and beta therapies, which could become a promising tool in the control of tumor progression. |
| first_indexed | 2024-03-09T11:29:15Z |
| format | Article |
| id | doaj.art-27571cb2ecf6460d87cbcb8c665bb3e6 |
| institution | Directory Open Access Journal |
| issn | 2073-4360 |
| language | English |
| last_indexed | 2024-03-09T11:29:15Z |
| publishDate | 2022-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Polymers |
| spelling | doaj.art-27571cb2ecf6460d87cbcb8c665bb3e62023-11-30T23:53:58ZengMDPI AGPolymers2073-43602022-03-01147140510.3390/polym14071405Nanomicelles of Radium Dichloride [<sup>223</sup>Ra]RaCl<sub>2</sub> Co-Loaded with Radioactive Gold [<sup>198</sup>Au]Au Nanoparticles for Targeted Alpha–Beta Radionuclide Therapy of OsteosarcomaBárbara Nayane Rosário Fernandes Souza0Elisabete Regina Fernandes Ramos Ribeiro1Aline Oliveira da Silva de Barros2Martha Sahylí Ortega Pijeira3Hericka Oliveira Kenup-Hernandes4Eduardo Ricci-Junior5Joel Félix Silva Diniz Filho6Clenilton Costa dos Santos7Luciana Magalhães Rebelo Alencar8Mohamed F. Attia9Sara Gemini-Piperni10Ralph Santos-Oliveira11Argonauta Nuclear Reactor Center, Nuclear Engineering Institute, Brazilian Nuclear Energy Commission, Rio de Janeiro 21941-906, BrazilArgonauta Nuclear Reactor Center, Nuclear Engineering Institute, Brazilian Nuclear Energy Commission, Rio de Janeiro 21941-906, BrazilArgonauta Nuclear Reactor Center, Nuclear Engineering Institute, Brazilian Nuclear Energy Commission, Rio de Janeiro 21941-906, BrazilArgonauta Nuclear Reactor Center, Nuclear Engineering Institute, Brazilian Nuclear Energy Commission, Rio de Janeiro 21941-906, BrazilLaboratory of Nanoradiopharmaceuticals and Synthesis of Novel Radiopharmaceuticals, Nuclear Engineering Institute, Brazilian Nuclear Energy Commission, Rio de Janeiro 21941-906, BrazilDEFARMED Laboratory, Faculdade de Farmácia, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-900, BrazilLaboratory of Biophysics and Nanosystems, Department of Physics, Federal University of Maranhão, São Luís 65080-805, BrazilLaboratory of Biophysics and Nanosystems, Department of Physics, Federal University of Maranhão, São Luís 65080-805, BrazilLaboratory of Biophysics and Nanosystems, Department of Physics, Federal University of Maranhão, São Luís 65080-805, BrazilCenter for Nanotechnology in Drug Delivery, Eshelman School of Pharmacy, Division of Pharmacoengineering and Molecular Pharmaceutics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USAInstituto de Ciências Biomédicas, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-902, BrazilArgonauta Nuclear Reactor Center, Nuclear Engineering Institute, Brazilian Nuclear Energy Commission, Rio de Janeiro 21941-906, BrazilAlpha and beta particulate radiation are used for non-treated neoplasia, due to their ability to reach and remain in tumor sites. Radium-223 (<sup>223</sup>Ra), an alpha emitter, promotes localized cytotoxic effects, while radioactive gold (<sup>198</sup>Au), beta-type energy, reduces radiation in the surrounding tissues. Nanotechnology, including several radioactive nanoparticles, can be safely and effectively used in cancer treatment. In this context, this study aims to analyze the antitumoral effects of [<sup>223</sup>Ra]Ra nanomicelles co-loaded with radioactive gold nanoparticles ([<sup>198</sup>Au]AuNPs). For this, we synthesize and characterize nanomicelles, as well as analyze some parameters, such as particle size, radioactivity emission, dynamic light scattering, and microscopic atomic force. [<sup>223</sup>Ra]Ra nanomicelles co-loaded with [<sup>198</sup>Au]AuNPs, with simultaneous alpha and beta emission, showed no instability, a mean particle size of 296 nm, and a PDI of 0.201 (±0.096). Furthermore, nanomicelles were tested in an in vitro cytotoxicity assay. We observed a significant increase in tumor cell death using combined alpha and beta therapy in the same formulation, compared with these components used alone. Together, these results show, for the first time, an efficient association between alpha and beta therapies, which could become a promising tool in the control of tumor progression.https://www.mdpi.com/2073-4360/14/7/1405alpha–beta therapybone cancerradium-223 dichlorideradioactive gold nanoparticlesnanomicelles |
| spellingShingle | Bárbara Nayane Rosário Fernandes Souza Elisabete Regina Fernandes Ramos Ribeiro Aline Oliveira da Silva de Barros Martha Sahylí Ortega Pijeira Hericka Oliveira Kenup-Hernandes Eduardo Ricci-Junior Joel Félix Silva Diniz Filho Clenilton Costa dos Santos Luciana Magalhães Rebelo Alencar Mohamed F. Attia Sara Gemini-Piperni Ralph Santos-Oliveira Nanomicelles of Radium Dichloride [<sup>223</sup>Ra]RaCl<sub>2</sub> Co-Loaded with Radioactive Gold [<sup>198</sup>Au]Au Nanoparticles for Targeted Alpha–Beta Radionuclide Therapy of Osteosarcoma Polymers alpha–beta therapy bone cancer radium-223 dichloride radioactive gold nanoparticles nanomicelles |
| title | Nanomicelles of Radium Dichloride [<sup>223</sup>Ra]RaCl<sub>2</sub> Co-Loaded with Radioactive Gold [<sup>198</sup>Au]Au Nanoparticles for Targeted Alpha–Beta Radionuclide Therapy of Osteosarcoma |
| title_full | Nanomicelles of Radium Dichloride [<sup>223</sup>Ra]RaCl<sub>2</sub> Co-Loaded with Radioactive Gold [<sup>198</sup>Au]Au Nanoparticles for Targeted Alpha–Beta Radionuclide Therapy of Osteosarcoma |
| title_fullStr | Nanomicelles of Radium Dichloride [<sup>223</sup>Ra]RaCl<sub>2</sub> Co-Loaded with Radioactive Gold [<sup>198</sup>Au]Au Nanoparticles for Targeted Alpha–Beta Radionuclide Therapy of Osteosarcoma |
| title_full_unstemmed | Nanomicelles of Radium Dichloride [<sup>223</sup>Ra]RaCl<sub>2</sub> Co-Loaded with Radioactive Gold [<sup>198</sup>Au]Au Nanoparticles for Targeted Alpha–Beta Radionuclide Therapy of Osteosarcoma |
| title_short | Nanomicelles of Radium Dichloride [<sup>223</sup>Ra]RaCl<sub>2</sub> Co-Loaded with Radioactive Gold [<sup>198</sup>Au]Au Nanoparticles for Targeted Alpha–Beta Radionuclide Therapy of Osteosarcoma |
| title_sort | nanomicelles of radium dichloride sup 223 sup ra racl sub 2 sub co loaded with radioactive gold sup 198 sup au au nanoparticles for targeted alpha beta radionuclide therapy of osteosarcoma |
| topic | alpha–beta therapy bone cancer radium-223 dichloride radioactive gold nanoparticles nanomicelles |
| url | https://www.mdpi.com/2073-4360/14/7/1405 |
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