Activation of the NLRP3 Inflammasome Increases the IL-1β Level and Decreases GLUT4 Translocation in Skeletal Muscle during Insulin Resistance

Activation of the NLRP3 Inflammasome Increases the IL-1β Level and Decreases GLUT4 Translocation in Skeletal Muscle during Insulin Resistance

Low-grade chronic inflammation plays a pivotal role in the pathogenesis of insulin resistance (IR), and skeletal muscle has a central role in this condition. NLRP3 inflammasome activation pathways promote low-grade chronic inflammation in several tissues. However, a direct link between IR and NLRP3...

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Bibliographic Details
Main Authors: Luan Américo-Da-Silva, Javiera Aguilera, Oscar Quinteros-Waltemath, Pablo Sánchez-Aguilera, Javier Russell, Cynthia Cadagan, Roberto Meneses-Valdés, Gina Sánchez, Manuel Estrada, Gonzalo Jorquera, Genaro Barrientos, Paola Llanos
Format: Article
Language:English
Published: MDPI AG 2021-09-01
Series:International Journal of Molecular Sciences
Subjects:
high-fat diet
myokines
caspase-1
GSDMD
NALP3
inflammation
Online Access:https://www.mdpi.com/1422-0067/22/19/10212

Internet

https://www.mdpi.com/1422-0067/22/19/10212

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