Phosphatidylinositol 3-Kinase/AKT Pathway Inhibition by Doxazosin Promotes Glioblastoma Cells Death, Upregulation of p53 and Triggers Low Neurotoxicity.

Phosphatidylinositol 3-Kinase/AKT Pathway Inhibition by Doxazosin Promotes Glioblastoma Cells Death, Upregulation of p53 and Triggers Low Neurotoxicity.

Glioblastoma is the most frequent and malignant brain tumor. Treatment includes chemotherapy with temozolomide concomitant with surgical resection and/or irradiation. However, a number of cases are resistant to temozolomide, as well as the human glioblastoma cell line U138-MG. We investigated doxazo...

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Bibliographic Details
Main Authors: Mariana Maier Gaelzer, Bárbara Paranhos Coelho, Alice Hoffmann de Quadros, Juliana Bender Hoppe, Silvia Resende Terra, Maria Cristina Barea Guerra, Vanina Usach, Fátima Costa Rodrigues Guma, Carlos Alberto Saraiva Gonçalves, Patrícia Setton-Avruj, Ana Maria Oliveira Battastini, Christianne Gazzana Salbego
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2016-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4849739?pdf=render

Internet

http://europepmc.org/articles/PMC4849739?pdf=render

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