Urolithin A Inactivation of TLR3/TRIF Signaling to Block the NF-κB/STAT1 Axis Reduces Inflammation and Enhances Antioxidant Defense in Poly(I:C)-Induced RAW264.7 Cells

Urolithin A Inactivation of TLR3/TRIF Signaling to Block the NF-κB/STAT1 Axis Reduces Inflammation and Enhances Antioxidant Defense in Poly(I:C)-Induced RAW264.7 Cells

Urolithin A is an active compound of gut-microbiota-derived metabolites of polyphenol ellagic acid that has anti-aging, antioxidative, and anti-inflammatory effects. However, the effects of urolithin A on polyinosinic acid-polycytidylic acid (poly(I:C))-induced inflammation remain unclear. Poly(I:C)...

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Bibliographic Details
Main Authors: Wen-Chung Huang, Chian-Jiun Liou, Szu-Chuan Shen, Sindy Hu, Jane C-J Chao, Chien-Yu Hsiao, Shu-Ju Wu
Format: Article
Language:English
Published: MDPI AG 2022-04-01
Series:International Journal of Molecular Sciences
Subjects:
urolithin A
poly(I:C)
TLR3
NF-κB
MAPK
Online Access:https://www.mdpi.com/1422-0067/23/9/4697

Internet

https://www.mdpi.com/1422-0067/23/9/4697

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