Biodegradable nanoparticulate co-delivery of flavonoid and doxorubicin: Mechanistic exploration and evaluation of anticancer effect in vitro and in vivo

Biodegradable nanoparticulate co-delivery of flavonoid and doxorubicin: Mechanistic exploration and evaluation of anticancer effect in vitro and in vivo

The proposed study involves delivering drug/bioactive using a single nanoplatform based on poly lactic-co-glycolic acid (PLGA) for better efficacy, synergistic effect, and reduced toxicity. PLGA was conjugated to doxorubicin (D1), and this conjugate was used for encapsulation of naringenin (D2) to d...

Full description

Bibliographic Details
Main Authors: Iliyas Khan, Bibekananda Sarkar, Gaurav Joshi, Kartik T. Nakhate, Ajazuddin, Anil K. Mantha, Raj Kumar, Ankur Kaul, Shubhra Chaturvedi, Anil K. Mishra, Umesh Gupta
Format: Article
Language:English
Published: Elsevier 2021-09-01
Series:Biomaterials and Biosystems
Subjects:
Dual drug delivery
Naringenin
Immunoblotting
Pharmacokinetics
Tumor regression
Online Access:http://www.sciencedirect.com/science/article/pii/S2666534421000155

Internet

http://www.sciencedirect.com/science/article/pii/S2666534421000155

Similar Items