Angiotensin II Receptor–Neprilysin Inhibitor Sacubitril/Valsartan Improves Endothelial Dysfunction in Spontaneously Hypertensive Rats

Angiotensin II Receptor–Neprilysin Inhibitor Sacubitril/Valsartan Improves Endothelial Dysfunction in Spontaneously Hypertensive Rats

BackgroundWe have previously demonstrated that antihypertensive treatment with renin‐angiotensin system inhibitors restores the impaired endothelium‐dependent hyperpolarization (EDH)–mediated responses in spontaneously hypertensive rats (SHRs). Herein, we investigated whether the angiotensin II rece...

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Bibliographic Details
Main Authors: Takunori Seki, Kenichi Goto, Yasuo Kansui, Toshio Ohtsubo, Kiyoshi Matsumura, Takanari Kitazono
Format: Article
Language:English
Published: Wiley 2017-10-01
Series:Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Subjects:
endothelial function
endothelial‐derived relaxant factor
hypertension
renin angiotensin system
Online Access:https://www.ahajournals.org/doi/10.1161/JAHA.117.006617

Internet

https://www.ahajournals.org/doi/10.1161/JAHA.117.006617

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