Patient‐ and xenograft‐derived organoids recapitulate pediatric brain tumor features and patient treatments

Patient‐ and xenograft‐derived organoids recapitulate pediatric brain tumor features and patient treatments

Abstract Brain tumors are the leading cause of cancer‐related death in children. Experimental in vitro models that faithfully capture the hallmarks and tumor heterogeneity of pediatric brain cancers are limited and hard to establish. We present a protocol that enables efficient generation, expansion...

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Bibliographic Details
Main Authors: Chiara Lago, Aniello Federico, Gloria Leva, Norman L Mack, Benjamin Schwalm, Claudio Ballabio, Matteo Gianesello, Luana Abballe, Isabella Giovannoni, Sofia Reddel, Sabrina Rossi, Nicolas Leone, Andrea Carai, Angela Mastronuzzi, Alessandra Bisio, Alessia Soldano, Concetta Quintarelli, Franco Locatelli, Marcel Kool, Evelina Miele, Luca Tiberi
Format: Article
Language:English
Published: Springer Nature 2023-12-01
Series:EMBO Molecular Medicine
Subjects:
brain tumors
organoids
patient‐derived
pediatric cancer
translational applications
Online Access:https://doi.org/10.15252/emmm.202318199

Internet

https://doi.org/10.15252/emmm.202318199

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