Coiled-Coil Domain-Containing 68 Downregulation Promotes Colorectal Cancer Cell Growth by Inhibiting ITCH-Mediated CDK4 Degradation

Coiled-Coil Domain-Containing 68 Downregulation Promotes Colorectal Cancer Cell Growth by Inhibiting ITCH-Mediated CDK4 Degradation

Coiled-coil domain-containing 68 (CCDC68) plays different roles in cancer and is predicted as a tumor suppressor in human colorectal cancer (CRC). However, the specific role of CCDC68 in CRC and the underlying mechanisms remain unknown. Here, we showed that CCDC68 expression was lower in CRC than th...

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Bibliographic Details
Main Authors: Cong Wang, Hongyan Li, Lei Wu, Xueli Jiao, Zihui Jin, Yujie Zhu, Ziling Fang, Xiaodong Zhang, Haishan Huang, Lingling Zhao
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-04-01
Series:Frontiers in Oncology
Subjects:
CCDC68
colorectal cancer
CDK4 degradation
ITCH
cell proliferation
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2021.668743/full

Internet

https://www.frontiersin.org/articles/10.3389/fonc.2021.668743/full

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