Analysis of Different Binding Modes for Tiagabine within the GAT-1 Transporter
The recently obtained cryo-electron microscopy structure (PDB code: 7SK2) of the human γ-aminobutyric acid transporter type 1 (hGAT-1) in complex with the antiepileptic drug, tiagabine, revealed a rather unexpected binding mode for this inhibitor in an inward-open state of the transporter. The simul...
| Hlavní autoři: | , |
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| Médium: | Článek |
| Jazyk: | English |
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MDPI AG
2022-11-01
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| Edice: | Biomolecules |
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| On-line přístup: | https://www.mdpi.com/2218-273X/12/11/1663 |