Analysis of Different Binding Modes for Tiagabine within the GAT-1 Transporter

The recently obtained cryo-electron microscopy structure (PDB code: 7SK2) of the human γ-aminobutyric acid transporter type 1 (hGAT-1) in complex with the antiepileptic drug, tiagabine, revealed a rather unexpected binding mode for this inhibitor in an inward-open state of the transporter. The simul...

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Bibliografiset tiedot
Päätekijät: Kamil Łątka, Marek Bajda
Aineistotyyppi: Artikkeli
Kieli:English
Julkaistu: MDPI AG 2022-11-01
Sarja:Biomolecules
Aiheet:
Linkit:https://www.mdpi.com/2218-273X/12/11/1663