RNA polymerase II pausing factor NELF in CD8+ T cells promotes antitumor immunity

RNA polymerase II pausing factor NELF in CD8+ T cells promotes antitumor immunity

Negative elongation factor B (NELFB) is one of the four subunits of the NELF complex that controls RNA polymerase II pausing. Here the authors show that, by associating with the key T cell transcription factor TCF1, NELFB is required for eliciting CD8 + T cell memory and anti-tumor immune responses....

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Bibliographic Details
Main Authors: Bogang Wu, Xiaowen Zhang, Huai-Chin Chiang, Haihui Pan, Bin Yuan, Payal Mitra, Leilei Qi, Hayk Simonyan, Colin N. Young, Eric Yvon, Yanfen Hu, Nu Zhang, Rong Li
Format: Article
Language:English
Published: Nature Portfolio 2022-04-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-022-29869-2

Internet

https://doi.org/10.1038/s41467-022-29869-2

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