Involvement of CD40-CD40L and ICOS-ICOSL in the development of chronic rhinosinusitis by targeting eosinophils

Involvement of CD40-CD40L and ICOS-ICOSL in the development of chronic rhinosinusitis by targeting eosinophils

BackgroundChronic rhinosinusitis (CRS), whose prevalence and pathogenesis are age-related, is characterized by nasal tissue eosinophil infiltration. CD40-CD40 ligand (CD40L) pathway involves in the eosinophil-mediated inflammation, and inducible co-stimulator (ICOS)–ICOS ligand (ICOSL) signal can st...

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Bibliographic Details
Main Authors: Aina Zhou, Chenxi Shi, Yuhui Fan, Yushuang Zheng, Jue Wang, Zhichen Liu, Huanxia Xie, Jisheng Liu, Qingqing Jiao
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-06-01
Series:Frontiers in Immunology
Subjects:
CD40-CD40L
ICOS-ICOSL
chronic rhinosinusitis
eosinophils
TNF-α
IL-5
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1171308/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2023.1171308/full

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