Molecular and metabolic regulation of immunosuppression in metastatic pancreatic ductal adenocarcinoma

Molecular and metabolic regulation of immunosuppression in metastatic pancreatic ductal adenocarcinoma

Abstract Immunosuppression is a hallmark of pancreatic ductal adenocarcinoma (PDAC), contributing to early metastasis and poor patient survival. Compared to the localized tumors, current standard-of-care therapies have failed to improve the survival of patients with metastatic PDAC, that necessecita...

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Bibliographic Details
Main Authors: Shailendra K. Gautam, Surinder K. Batra, Maneesh Jain
Format: Article
Language:English
Published: BMC 2023-07-01
Series:Molecular Cancer
Subjects:
Immunosuppression
Pre-metastatic niche
Exosomes
Non-coding RNA
Microbiome
Immune and metabolic checkpoints
Online Access:https://doi.org/10.1186/s12943-023-01813-y

Internet

https://doi.org/10.1186/s12943-023-01813-y

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