Insilico prediction and functional analysis of nonsynonymous SNPs in human CTLA4 gene

Abstract The CTLA4 receptor is an immune checkpoint involved in the downregulation of T cells. Polymorphisms in this gene have been found to be associated with different diseases like rheumatoid arthritis, autosomal dominant immune dysregulation syndrome, juvenile idiopathic arthritis and autoimmune...

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Bibliographic Details
Main Authors: Muhammad Irfan, Talha Iqbal, Sakina Hashmi, Uzma Ghani, Attya Bhatti
Format: Article
Language:English
Published: Nature Portfolio 2022-11-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-022-24699-0