Opinion: more mouse models and more translation needed for ALS

Opinion: more mouse models and more translation needed for ALS

Abstract Amyotrophic lateral sclerosis is a complex disorder most of which is ‘sporadic’ of unknown origin but approximately 10% is familial, arising from single mutations in any of more than 30 genes. Thus, there are more than 30 familial ALS subtypes, with different, often unknown, molecular patho...

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Bibliographic Details
Main Authors: Elizabeth M.C. Fisher, Linda Greensmith, Andrea Malaspina, Pietro Fratta, Michael G. Hanna, Giampietro Schiavo, Adrian M. Isaacs, Richard W. Orrell, Thomas J. Cunningham, Abraham Acevedo Arozena
Format: Article
Language:English
Published: BMC 2023-05-01
Series:Molecular Neurodegeneration
Subjects:
Amyotrophic lateral sclerosis
Motor neuron disease
Mouse models
Patient stratification
Translation
Online Access:https://doi.org/10.1186/s13024-023-00619-2

Internet

https://doi.org/10.1186/s13024-023-00619-2

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