Oligomeric Alpha-Synuclein and STX-1A from Neural-Derived Extracellular Vesicles (NDEVs) as Possible Biomarkers of REM Sleep Behavior Disorder in Parkinson’s Disease: A Preliminary Cohort Study

Oligomeric Alpha-Synuclein and STX-1A from Neural-Derived Extracellular Vesicles (NDEVs) as Possible Biomarkers of REM Sleep Behavior Disorder in Parkinson’s Disease: A Preliminary Cohort Study

REM sleep behavior disorder (RBD) has a tighter link with synucleinopathies than other neurodegenerative disorders. Parkinson’s Disease (PD) patients with RBD have a more severe motor and cognitive impairment; biomarkers for RBD are currently unavailable. Synaptic accumulation of α-Syn oligomers and...

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Bibliographic Details
Main Authors: Mario Meloni, Cristina Agliardi, Franca Rosa Guerini, Francesca Lea Saibene, Anna Vera Milner, Milena Zanzottera, Elisabetta Bolognesi, Monica Puligheddu, Michela Figorilli, Jorge Navarro, Mario Clerici
Format: Article
Language:English
Published: MDPI AG 2023-05-01
Series:International Journal of Molecular Sciences
Subjects:
oligomeric alpha-synuclein
extracellular vesicles
exosomes
REM sleep behavior disorder (RBD)
Parkinson’s disease (PD)
Online Access:https://www.mdpi.com/1422-0067/24/10/8839

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https://www.mdpi.com/1422-0067/24/10/8839

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