Reduction in O-GlcNAcylation Mitigates the Severity of Inflammatory Response in Cerulein-Induced Acute Pancreatitis in a Mouse Model

Reduction in O-GlcNAcylation Mitigates the Severity of Inflammatory Response in Cerulein-Induced Acute Pancreatitis in a Mouse Model

Acute pancreatitis (AP) involves premature trypsinogen activation, which mediates a cascade of pro-inflammatory signaling that causes early stages of pancreatic injury. Activation of the transcription factor κB (NF-κB) and secretion of pro-inflammatory mediators are major events in AP. O-GlcNAc tran...

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Bibliographic Details
Main Authors: Mackenzie Moore, Nandini Avula, Alicia Wong, Megan Beetch, Seokwon Jo, Emilyn U. Alejandro
Format: Article
Language:English
Published: MDPI AG 2022-02-01
Series:Biology
Subjects:
O-GlcNAc transferase (OGT)
O-GlcNAcylation
pancreas
pancreatitis
acute pancreatitis
cerulein
Online Access:https://www.mdpi.com/2079-7737/11/3/347

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https://www.mdpi.com/2079-7737/11/3/347

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