N-acetylcysteine as add-on to antidepressant medication in therapy refractory major depressive disorder patients with increased inflammatory activity: study protocol of a double-blind randomized placebo-controlled trial

N-acetylcysteine as add-on to antidepressant medication in therapy refractory major depressive disorder patients with increased inflammatory activity: study protocol of a double-blind randomized placebo-controlled trial

Abstract Background A subgroup of depressed patients with increased inflammatory activity was shown to be more susceptible to develop Treatment Resistant Depression (TRD). Earlier studies with anti-inflammatory drugs have shown benefits in the treatment of major depressive disorder (MDD), but the ef...

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Bibliographic Details
Main Authors: Chenghao Yang, Fokko J. Bosker, Jie Li, Robert A. Schoevers
Format: Article
Language:English
Published: BMC 2018-09-01
Series:BMC Psychiatry
Subjects:
N-acetylcysteine
Treatment resistant depression
Inflammatory activity
Biomarkers
Brain activity
Online Access:http://link.springer.com/article/10.1186/s12888-018-1845-1

Internet

http://link.springer.com/article/10.1186/s12888-018-1845-1

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