A new fasciocutaneous flap model identifies a critical role for endothelial Notch signaling in wound healing and flap survival

Abstract Flap surgery is a common treatment for severe wounds and a major determinant of surgical outcome. Flap survival and healing depends on adaptation of the local flap vasculature. Using a novel and defined model of fasciocutaneous flap surgery, we demonstrate that the Notch ligand Delta-like 1...

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Bibliographic Details
Main Authors: Khaled Dastagir, Jaba Gamrekelashvili, Nadjib Dastagir, Anne Limbourg, Dustin Kijas, Tamar Kapanadze, Peter M. Vogt, Florian P. Limbourg
Format: Article
Language:English
Published: Nature Portfolio 2023-08-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-023-39722-1