Acute Protective Effects of Simvastatin in the Rat Model of Renal Ischemia-Reperfusion Injury: It Is Never Too Late for the Pretreatment

Acute Protective Effects of Simvastatin in the Rat Model of Renal Ischemia-Reperfusion Injury: It Is Never Too Late for the Pretreatment

Acute pretreatment with a single i.v. bolus injection of simvastatin (1 mg/kg) significantly protects rat kidney injured by ischemia-reperfusion (I/R) (45 min + 6 h). We aimed to determine the optimal timing of such a pretreatment. The effects of both injections of simvastatin before ischemia and re...

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Bibliographic Details
Main Authors: Zoran Todorović, Zorica Nešić, Radan Stojanović, Gordana Basta-Jovanović, Sanja Radojević-Škodrić, Ružca Veličković, Prabal K. Chatterjee, Christoph Thiemermann, Milica Prostran
Format: Article
Language:English
Published: Elsevier 2008-01-01
Series:Journal of Pharmacological Sciences
Online Access:http://www.sciencedirect.com/science/article/pii/S134786131931401X

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http://www.sciencedirect.com/science/article/pii/S134786131931401X

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