New molecular mechanisms in cholangiocarcinoma: signals triggering interleukin-6 production in tumor cells and KRAS co-opted epigenetic mediators driving metabolic reprogramming

New molecular mechanisms in cholangiocarcinoma: signals triggering interleukin-6 production in tumor cells and KRAS co-opted epigenetic mediators driving metabolic reprogramming

Abstract Background Cholangiocarcinoma (CCA) is still a deadly tumour. Histological and molecular aspects of thioacetamide (TAA)-induced intrahepatic CCA (iCCA) in rats mimic those of human iCCA. Carcinogenic changes and therapeutic vulnerabilities in CCA may be captured by molecular investigations...

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Bibliographic Details
Main Authors: Leticia Colyn, Gloria Alvarez-Sola, M. Ujue Latasa, Iker Uriarte, Jose M. Herranz, Maria Arechederra, George Vlachogiannis, Colin Rae, Antonio Pineda-Lucena, Andrea Casadei-Gardini, Federica Pedica, Luca Aldrighetti, Angeles López-López, Angeles López-Gonzálvez, Coral Barbas, Sergio Ciordia, Sebastiaan M. Van Liempd, Juan M. Falcón-Pérez, Jesus Urman, Bruno Sangro, Silve Vicent, Maria J. Iraburu, Felipe Prosper, Leonard J. Nelson, Jesus M. Banales, Maria Luz Martinez-Chantar, Jose J. G. Marin, Chiara Braconi, Christian Trautwein, Fernando J. Corrales, F. Javier Cubero, Carmen Berasain, Maite G. Fernandez-Barrena, Matias A. Avila
Format: Article
Language:English
Published: BMC 2022-05-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Cholangiocarcinoma
Bile
Inflammation
Interleukin-6
KRAS
G9a histone methyl-transferase
Online Access:https://doi.org/10.1186/s13046-022-02386-2

Internet

https://doi.org/10.1186/s13046-022-02386-2

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